Liam Holt, PhD

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Assistant Professor of Biochemistry and Molecular Pharmacology

Ph.D., 2008 University of California, San Francisco

LAB WEBSITE:
The Holt Lab

Contact Information

Institute for Systems Genetics

New York University

ALCS West, Rm 506

430 East 29th Street

New York, N.Y. 10016

Tel.: (646) 501-4597

E-mail: liam.holt@nyumc.org

Lab Website: http://mcb.berkeley.edu/labs/holt/


Research Summary

·       Synthetic biology to understand how signaling networks drive stem-cell differentiation and cancer

·       Computational microscopy to understand the biophysics of cells. 

We are creating synthetic signaling networks to control stem-cell differentiation as a pilot project for the HGP-write project; we are using ancestral resurrection to understand how kinases evolved their modern control and how this control goes awry in cancer; and we are using microfluidics and genetically encoded nanoparticles to study the structure of the cytoplasm and nucleoplasm and how cells respond to mechanical stress.

Selected Publications: 

Selected Publications:

·       Boeke JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R,Chakravarti A, Cornish VW, Holt L, et al GENOME ENGINEERING. The Genome Project-Write. Science. 2016 Jul 8;353(6295):126-7. doi: 10.1126/science.aaf6850. Epub 2016 Jun 2. PubMed PMID: 27256881.

·       Joyner RP, Tang JH, Helenius J, Dultz E, Brune C, Holt LJ, Huet S, Müller DJ, Weis K. A glucose-starvation response regulates the diffusion of macromolecules. Elife. 2016 Mar 22;5. pii: e09376. doi: 10.7554/eLife.09376. PubMed PMID:27003290; PubMed Central PMCID: PMC4811765.

·       Howard CJ, Hanson-Smith V, Kennedy KJ, Miller CJ, Lou HJ, Johnson AD, Turk BE, Holt LJ. Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity. Elife. 2014 Oct 13;3. doi: 10.7554/eLife.04126. PubMed PMID: 25310241; PubMed Central PMCID: PMC4228266.

·       Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO. Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science. 2009 Sep 25;325(5948):1682-6. doi: 10.1126/science.1172867. PubMed PMID: 19779198; PubMed Central PMCID: PMC2813701.

·       Holt LJ, Krutchinsky AN, Morgan DO. Positive feedback sharpens the anaphase switch. Nature. 2008 Jul 17;454(7202):353-7. doi: 10.1038/nature07050. Epub 2008 Jun 15. PubMed PMID: 18552837; PubMed Central PMCID: PMC2636747.