Ubiquitin-Proteasome System Identified As Key Regulator of Stem Cell Pluripotency

Date: 
Wed, 12/05/2012 - 2:06am

Members in the Aifantis Lab studying the role of posttranslational modifications in stem cell pluripotency and differentiation, published a paper in Cell Stem Cell this week, identifying the ubiquitin-proteasome system as a key regulator of stem cell pluripotency.  The authors identified ubiquitinated proteins with important roles during embryonic stem cell (ESC) differentiation along with ubiquitin enzymes that are essential for regulation of pluripotency, ESC differentiation, and homeostasis.  The first author, Shannon Buckley, is a postdoctoral trainee in the Kimmel Center for Stem Cell Biology and the senior author, Dr. Aifantis, is a member of the Kimmel Center for Stem Cell Biology. 

 

To view the paper click here:
Thumbnail: