Stem Cells Control Hair Pigmentation and Growth

Sat, 06/11/2011 - 6:56am


The June 10th issue of Cell features an article by Dr. Mayumi Ito’s group on hair pigmentation. The authors identify Wnt signaling as a key pathway in linking melanocyte stem cell (McSCs) and epithelial stem cell (EpSCs) activity during hair follicle regeneration. Wnt signaling is essential for the coordinated action of these two stem cell populations and is thus critical for hair pigmentation. Wnt activation in McSCs drives their differentiation into pigment-producing melanocytes. In EpSCs, Wnt signaling dictates hair follicle formation and regulates McSC proliferation during hair regeneration. The image on the cover of this issue is provided by Dr. Ito’s group and a PaperFlick is available on the journal’s website , summarizing the research findings. (Rabbani et al. Cell 145, June 10, 2011, cover MIto

Dr. Mayumi Ito is an Assistant Professor in the Department of Dermatology and a member of the Kimmel Center for Stem Cell Biology.