Shannon Buckley: 2013 Kimmel Senior Fellow

Mon, 09/23/2013 - 11:30pm


The Helen L. and Martin S. Kimmel Center for Stem Cell Biology has named Shannon Buckley, Ph.D., as the 2013 Helen L. and Martin S. Kimmel Senior Fellow in Stem Cell Biology.   This fellowship is awarded annually to NYU's most promising post-doctoral researchers in the area of stem cell biology. Shannon is currently a post-doctoral fellow in the laboratory of Dr. Iannis Aifantis in the Department of Pathology and works on the molecular mechanisms that regulate stem cell fate decisions. In the Aifantis Lab, Shannon has been working on the role of the ubiquitin proteasome system (UPS) in stem cell pluripotency, self-renewal, and differentiation using both pluripotent and adult stem cells.

Shannon has identified ubiquitin E3 ligases that regulate cellular reprogramming, pluripotency and differentiation, as well as determined substrates. Furthermore, she focused on the role of E3 ligase Fbxw7 in regulating leukemic stem cells in chronic myeloid leukemia and showed that cMyc ubiquitintation by Fbxw7 regulates initiation and progression of the disease. Her work has shown that post-translational modifications of proteins, specifically by the ubiquitin-proteasome system, control stem cell fate decisions and pluripotency.

During her Kimmel Stem Cell fellowship, Shannon plans to use genomic and proteomic approaches to further elucidate substrate-ligase interactions from her work in embryonic stem cells to provide clues of the molecular mechanisms underlying pluripotency, self-renewal, differentiation, and cancer transformation. As an initial starting point her work will focus on the E3 ligase Ubr5 identified in her post-doctoral research to regulate stem cell pluripotency and further define the role of Ubr5 in development and hematopoiesis as well as identify Ubr5 target substrates.

The Kimmel Center for Stem Cell Biology post-doctoral fellows program is designed to provide additional sources of support for more senior post-doctoral fellows who are preparing for an independent research career in stem cell biology. The fellowships are supported generously from funds provided to the Helen L. and Martin S. Kimmel Center for Stem Cell Biology by Mrs. Helen L. Kimmel and her late husband, Martin S. Kimmel.

To read more about previous Kimmel Senior Fellows click here