Philipp Leucht, MD

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LAB WEBSITE:
Philipp Leucht Lab
RESEARCH THEMES:
Bone regeneration, fracture healing, stem cell homing, neural crest/mesoderm, growth factors
KEYWORDS:
Aging, Notch, Wnt, bone healing, BMP, osteoprogenitor cells, osteoblasts

Contact Information

Departments of Orthopaedic Surgery and Cell Biology
NYU School of Medicine
550 First Avenue, MSB-617
New York, NY 10016
Tel: (646) 501-0291
E-Mail : philipp.Leucht@nyumc.org


 

We focus on three major areas of bone healing: (1) the underlying cell and molecular regulatory mechanisms involved in skeletal development and fracture repair, (2) the role of the mechanical environment during fracture repair, and (3) stem cell-based tissue engineering strategies to enhance bone regeneration. Assays performed in the lab include, but are not limited to in vivo fracture healing models in mouse, rat and rabbit, bone histomorphometry, genetically modified mouse models, in situ hybridization, microCT analysis, and routine cell and molecular biology techniques. We were recently funded to examine the embryonic origin of skeletal stem cells, and how the embryonic origin affects their regenerative potential. Other studies investigate the effect of Wnt3a, a pro-osteogenic protein, on aged bone grafts. This line of work integrates basic science research in the field of bone regeneration with a relatively new target indication: enhancing the osteogenic potential of aged bone autograft.

Selected Publications: 
  • Leucht P, Jiang J, Cheng D, Liu B, Dhamdhere G, Fang M, Monica SD, Urena JJ,
    Cole W, Smith RL, Castillo AB, Longaker MT, and Helms JA. Wnt3a reverses the
    fatty degeneration of aged bone marrow through its control of mesenchymal stem
    cell fate. J Bone Joint Surg Am, 2013 Jul 17;95(14):1278-1288.
  • Leucht P, Monica SD, Temiyasathit S, Castillo AB, Lenton K, Manu A, Longaker
    MT, Jacobs C, Brunski J, Helms JA. Primary cilia act as mechanosensors during
    bone healing around an implant. Medical Engineering&Physics 2013;(35), pp.
    392-402
  • Minear SC*, Leucht P*, Jiang J, Liu B, Zeng A, Fuerer C, Nusse R, Helms JA.
    Wnt proteins promote bone regeneration. Science - Translational Medicine 2010
    Apr 28;2(29):29ra30 *=co-first authors
  • Minear SC, Leucht P, Miller S, Helms, JA. rBMP represses Wnt signaling and
    influences skeletal progenitor cell fate specification during bone repair. J Bone
    Mineral Research 2010 Jun;25(6):1196-207.
  • Leucht P, Kim JB, Amasha RR, James WA, Girod S, Helms JA. Embryonic
    origin and Hox status determine progenitor cell fate during adult bone
    regeneration. Development 2008 Aug;135:2845-2854