Philipp Leucht, MD
Philipp Leucht Lab
Bone regeneration, fracture healing, stem cell homing, neural crest/mesoderm, growth factors
Aging, Notch, Wnt, bone healing, BMP, osteoprogenitor cells, osteoblasts
Departments of Orthopaedic Surgery and Cell Biology
NYU School of Medicine
550 First Avenue, MSB-617
New York, NY 10016
Tel: (646) 501-0291
E-Mail : philipp.Leucht@nyumc.org
We focus on three major areas of bone healing: (1) the underlying cell and molecular regulatory mechanisms involved in skeletal development and fracture repair, (2) the role of the mechanical environment during fracture repair, and (3) stem cell-based tissue engineering strategies to enhance bone regeneration. Assays performed in the lab include, but are not limited to in vivo fracture healing models in mouse, rat and rabbit, bone histomorphometry, genetically modified mouse models, in situ hybridization, microCT analysis, and routine cell and molecular biology techniques. We were recently funded to examine the embryonic origin of skeletal stem cells, and how the embryonic origin affects their regenerative potential. Other studies investigate the effect of Wnt3a, a pro-osteogenic protein, on aged bone grafts. This line of work integrates basic science research in the field of bone regeneration with a relatively new target indication: enhancing the osteogenic potential of aged bone autograft.
Leucht P, Jiang J, Cheng D, Liu B, Dhamdhere G, Fang M, Monica SD, Urena JJ,
Cole W, Smith RL, Castillo AB, Longaker MT, and Helms JA. Wnt3a reverses the
fatty degeneration of aged bone marrow through its control of mesenchymal stem
cell fate. J Bone Joint Surg Am, 2013 Jul 17;95(14):1278-1288.
Leucht P, Monica SD, Temiyasathit S, Castillo AB, Lenton K, Manu A, Longaker
MT, Jacobs C, Brunski J, Helms JA. Primary cilia act as mechanosensors during
bone healing around an implant. Medical Engineering&Physics 2013;(35), pp.
Minear SC*, Leucht P*, Jiang J, Liu B, Zeng A, Fuerer C, Nusse R, Helms JA.
Wnt proteins promote bone regeneration. Science - Translational Medicine 2010
Apr 28;2(29):29ra30 *=co-first authors
Minear SC, Leucht P, Miller S, Helms, JA. rBMP represses Wnt signaling and
influences skeletal progenitor cell fate specification during bone repair. J Bone
Mineral Research 2010 Jun;25(6):1196-207.
Leucht P, Kim JB, Amasha RR, James WA, Girod S, Helms JA. Embryonic
origin and Hox status determine progenitor cell fate during adult bone
regeneration. Development 2008 Aug;135:2845-2854