Glenn I. Fishman, MD

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William Goldring Professor of Medicine
Director, Leon H. Charney Division of Cardiology
M.D., 1983 Stanford University

LAB WEBSITE:
Fishman Lab
RESEARCH THEMES:
Stem Cell Biology, Differentiation
KEYWORDS:
Cardiomyocyte, Electrophysiology, ES Cell, IPS Cell, Purkinje Cell, Cardiac Conduction System

Contact Information

NYU School of Medicine
Division of Cardiology
522 First Avenue, Smilow 801
New York, NY 10016
Tel: (212) 263-3967
E-mail: glenn.fishman@nyumc.org
Website: http://www.med.nyu.edu/biosketch/fishmg01#


Developmental biology and electrophysiology of cardiac stem cells.

 

 

My laboratory studies cardiovascular electrophysiology and arrhythmia mechanisms.  Our work utilizes embryonic stem cells, induced pluripotent stem cells and isolated embryonic hearts as model systems to explore the cell fate decision of cardiac progenitors as they mature into specific sub-types of cardiomyocytes, with a particular focus on cells that comprise the specialized conduction system network.

Selected Publications: 
  • Park, D. S., Tompkins, R. O., Liu, F.-Y., Zhang, J., Shin, D., Phoon, C. K. L., Zavadil, J., and Fishman, G. I. (2013). Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system Biol Open 2(9):968-78. PMID: 24143284
  • Danielson, L. S., Park, D. S., Rotllan, N., Chamorro-Jorganes, A., Guijarro, M. V., Fernandez-Hernando, C., Fishman, G. I., Phoon, C. K., and Hernando, E. (2013) Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis, FASEB J. 27(4):1460-7. PMID: 23271053
  • Turbendian, H. K., Gordillo, M., Tsai, S.-Y., Lu, J., Kang, G., Liu, T.-C., Fishman, G. I., and Evans, T. (2013). GATA factors efficiently direct cardiac fate from embryonic stem cells Development 140(8):1639-44. PMID: 23487308
  • Rentschler S, Yen AH, Lu J, Petrenko NB, Lu MM, Patel VV, Fishman GI, Epstein JE. (2012). Myocardial Notch Signaling Reprograms Cardiomyocytes to a Conduction-Like Phenotype. Circulation 126(9):1058-66. PMID: 22837163
  • Remo BF, Qu J. Giovannone S, Volpicelli FM, Lent DS, Park DS, Liu F, Zhang J, Fishman GI. (2011). Phosphatase Resistant Gap Junctions Inhibit Pathologic Remodeling and Prevent Arrhythmias.  Circulation Research 108(12):1459-66. PMID: 21527737
  • Pallante BA, Giovannone S, Liu F-Y, Zhang J, Liu N, Kang G, Dun W, Boyden PA, Fishman GI. (2010). Contactin-2 Expression in the Cardiac Purkinje Fiber Network. Circ Arrhythmia Electrophys 3(2):186-94. PMID: 20110552
  • Kang G, Giovannone SF, Liu N, Liu FY, Zhang J, Priori SG, Fishman GI. (2010). Purkinje Cells from RyR2 Mutant Mice are Highly Arrhythmogenic but Responsive to Targeted Therapy. Circ Res 107(4):512-9. PMID: 20595652
  • Sotoodehnia N, et al. (2010). Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.  Nature Genetics 42(12):1068-76. PMID: 21076409
  • Wolf CM, Wang L. Alcalai R, Pizard A, Burgon P, Ahmed F, Sherwood MC, Branco DM, Wakimoto H, Fishman GI, See V, Stewart CL, Connor DA, Berul CI, Seidman CE, Seidman JG. (2008). Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis triggered cardiac conduction system disease. Journal of Molecular and Cellular Cardiology 44(2):293-303. PMID: 18182166
  • Kalcheva N, Qu J, Sandeep N, Garcia L, Zhang J, Wang Z, Lampe P, Suadicani SO, Spray DC, Fishman GI.  (2007). Gap junction remodeling and cardiac arrythmogenesis in a murine model of oculodentodigital dysplasia.  Proc. Natl Acad Sci, USA. 104(51):20512-6. PMID: 18077386
  • Yang L, Cai CL, Lin L, Qyang Y, Chung C, Monteiro RM, Mummery CL, Fishman GI, Cogen A, Evans S. (2006).  Isl1Cre reveals a common Bmp pathway in heart and limb development. Development 133(8):1575-85. PMID: 16556916
  • Morley, GE., Danik, SB., Bernstein, S., Sun, Y., Rosner, G., Gutstein, DE and GI Fishman. (2005). Reduced Intercellular Coupling Leads to Paradoxical Propagation across the Purkinje-Ventricular Junction and Aberrant Myocardial Activation.  Proc. Natl Acad Sci, USA 15;102(11):4126-9. PMID: 15753312
  • Dor, Y., V. Djonov, R. Abramovitch, A. Itin, G.I. Fishman, P. Carmeliet, G. Goelman and E. Keshet. (2002) Conditional switching of VEGF expression provides new insights into adult neovascularization and pro-angiogenic therapy.  EMBO Journal 21: 1939-1947. PMID: 11953313
  • Rentschler, S., Zander, J., Burns, K., France, D., Levine, R., Porter, G., Rivkees, S.A., Morley, G.E. and G.I. Fishman. (2002).  Neuregulin-1 Promotes Formation of the Murine Cardiac Conduction System.   Proc. Natl. Acad. Sci. USA 99: 10464-10469. PMID: 12149465
  • Dor, Y, T.D. Camenisch, A Itin, G.I. Fishman, J.A. McDonald, P.Carmeliet and E. Keshet. (2001)  A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects.  Development 128, 1531-1538. PMID: 11290292
  • Rentschler, S., H. Tamaddon, K. Degenhardt, D. Sassoon, G.E. Morley and G.I. Fishman. (2001)  Visualization and Functional Characterization of the Developing Murine Cardiac Conduction System.  Development 128, 1785-1792. PMID: 11311159
  • Gutstein, D.E., G.E. Morley, H. Tamaddon, D. Vaidya, M.D. Schneider, J. Chen, K.R. Chien, H. Stuhlmann and G.I. Fishman. (2001). Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of Connexin43. Circulation Research 88: 333 - 339. PMID: 11179202
  • Ai, Z, A. Fischer, D.C. Spray, A.M.C. Brown and G.I. Fishman (2000).  Wnt-1 Regulation of Connexin43 in Cardiac Myocytes. J. Clin Invest. 105:161-171. PMID: 10642594
  • Lee, P., G. Morley, Q. Huang, A. Fischer, S. Seiler, J.W. Horner, S.M. Factor, V. Dhananjay, J. Jalife and G.I. Fishman (1998)  Conditional lineage ablation to model human diseases. Proc. Natl. Acad. Sci, USA. 95: 11371-11376. PMID: 9736743
  • McDonald, T.V., Z. Yu, Z. Ming, E. Palma, M.B. Meyers, K-W Wang, S.N.A. Goldstein and G.I.  Fishman. (1997)  A minK-HERG complex regulates the cardiac potassium current IKr  Nature 388: 289-292. PMID: 9230439