E. Jane Albert Hubbard, PhD
Professor of Pathology
Ph.D., 1993 Columbia University
Signal Transduction, Stem Cell Biology, Pattern Formation, Growth Control
C. elegans, Notch, Insulin, Cell Proliferation, Germ Line
Skirball Institute of Biomolecular Medicine
New York University School of Medicine
540 First Ave. 4th floor
New York, NY 10016
Office Tel: (212) 263-7154
Lab Tel: (212) 263-7533
[Preferred method of contact: e-mail]
My lab studies the developmental and physiological control of stem cell proliferation and differentiation using the C. elegans germ line as a model system.
During the development and maintenance of tissues and organs, cells must decide whether, when, where and how much to proliferate. Improper control of cell proliferation and differentiation can lead to stem cell failure, developmental defects and cancer. We focus on the control of pattern and extent of germline proliferation as a model. We are interested in cell-cell signaling between the soma and germ line as well as more global and environmental signaling mechanisms that influence germline proliferation and differentiation.
We began these studies with the analysis of C. elegans mutations that cause germline tumors. We have uncovered the key anatomical and molecular events that underlie tumor formation in these mutants: they result from a delay in the initial onset of differentiation during germline development. This delay causes an inappropriate cell-cell interaction between particular somatically derived gonad cells and undifferentiated (mitotically competent) germ cells. Using our detailed knowledge of germline tumor formation, we have designed and carried out large-scale genetic screens – both classical and RNAi-based screens – to identify genes that influence tumor formation. These kinds of approaches have implicated conserved signaling pathways including the insulin/IGF, TOR, and TGFß pathways. Moreover, our studies reveal molecular mechanisms whereby the stem/progenitor pool responds to nutritional and sensory cues in conjunction with previously known niche cues via Notch pathway signaling.
In collaboration with computer science groups we are also pursuing computational modeling methods that can be applied to stem/developmental biology.
Research is supported by the National Institutes of Health, the New York State Stem Cell Foundation
- E.J.A. Hubbard, D.Z. Korta, D. Dalfó (2013) Physiological control of germline development, Adv Exp Med Biol 757:101-131 (review article). PMID: 22872476
- D. Dalfó, D. Michaelson, E.J.A. Hubbard (2012) Sensory Regulation of the C. elegans Germline through TGF-b-Dependent Signaling in the Niche. Current Biology 22:712-719. PMID: 22483938
- D.Z. Korta, S. Tuck, E.J.A. Hubbard (2012) S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells. Development 139:859-870. PMID: 22278922
- Y. Setty, D. Dalfó, D.Z. Korta, E.J.A. Hubbard, H. Kugler, 2012. A model of stem cell population dynamics: in silico analysis and in vivo validation. Development 139:47-56. PMID: 22147952
- E.J.A. Hubbard (2011) Insulin and germline proliferation in Caenorhabditis elegans. Vitam Horm 87:61-77 (review article). PMID: 22127237
- D.Z. Korta, E.J.A. Hubbard (2010) Soma-germline interactions that influence germline proliferation in C. elegans. Developmental Dynamics 239:1449–1459. (peer-reviewed review article) PMID: 20225254
- D. Michaelson, D.Z. Korta, Y. Capua, E.J.A. Hubbard (2010) Insulin signaling promotes germline proliferation in C. elegans. Development 137(4):671-80. PMID: 20110332
- M. McGovern, R. Voutev, J. Maciejowski, A. Corsi, E.J.A. Hubbard (2009). A “latent niche” mechanism for tumor initiation. Proc. Natl. Acad. Sci. USA 106:11617-22. PMID: 19564624
- S. Nadarajan, J.A. Govindan, M. McGovern, E.J.A.Hubbard, D. Greenstein (2009) MSP and GLP-1/Notch signaling coordinately regulate actomyosin-dependent cytoplasmic streaming and oocyte growth in C. elegans. Development 136:2223-2234. PMID: 19502484
- R. Voutev, R. Keating, E.J.A. Hubbard, L.G. Vallier, (2009) Characterization of the C. elegans Islet LIM-homeodomain ortholog, lim-7. FEBS Letters 583:456-464. PMID: 19116151
- N. Kam, H. Kugler, R. Marelly, L. Appleby, J. Fisher, A. Pnueli, D. Harel, M.J. Stern, E.J.A Hubbard. (2008) A scenario-based approach to modeling development: A Prototype Model of C. elegans Vulval Cell Fate Specification. Developmental Biology 323:1-5. PMID: 18706404
- R. Voutev, and E. J. A. Hubbard. (2008) A “FLP-out” system for controlled gene expression in C. elegans. Genetics 180:103-119. PMID: 18723890
- A. Sadot, J. Fisher, D. Barak, Y. Admanit, M.J. Stern, E.J.A. Hubbard, and D. Harel (2008) Toward Verified Biological Models. IEEE/ACM Trans Comput Biol Bioinform. Apr-Jun;5(2):223-34 [featured cover article]. PMID: 18451431
- E. J. A. Hubbard (2007) C. elegans germ line: a model for stem cell biology. Developmental Dynamics 236:3343-3357 (review article). PMID: 17948315