Daniel J Ceradini, MD

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Assistant Professor of Plastic Surgery
Director of Composite Tissue Allotransplantation
Director of IRPS Laboratories
Associate Director of Microsurgery
M.D., 2000 New York University School of Medicine

LAB WEBSITE:
Ceradini Lab
RESEARCH THEMES:
Stem Cell Biology, Vascular Biology, Transplant Biology
KEYWORDS:
Tissue Regeneration, Stem Cell Trafficking, Composite Tissue Allotransplantation, Tissue Engineering, Hypoxia, Diabetes, Aging, Wound Healing

Contact Information

New York University School of Medicine
305 E 33rd Street.
New York, NY 10016
Office Tel: (212) 263-3030
Lab Tel: (212) 263-8745
E-mail: Ceradd01@nyumc.org


Physiologic properties of stem/progenitor cells and how they can be manipulated for tissue regeneration, tissue engineering, and composite tissue allotransplantation.

Organismal development, growth, and tissue regeneration following injury is critically dependent on plasticity of vascular networks and local tissue oxygen tension.  In specific disease states such as diabetes or in advanced aging, this plasticity is significantly altered, resulting in a diminished ability to repair damaged tissues.  In tissue and organ engineering, the presence of a functional vasculature is the most significant rate-limiting step in generating substantial constructs ex vivo as well as their integration into the host vasculature in vivo.  In composite tissue allotransplantation, the interplay between the allograft vasculature and host immune system plays a critical role in the rejection response.   Thus, we believe that understanding the mechanisms of stem/progenitor mediated vascular regeneration and the interplay between the vasculature and circulating/resident stem cells has a broad impact on human disease and tissue engineering.

Our lab investigates novel methods to modulate stem cells and/or their functional environment using several preclinical models in mice and rats.   Specifically, we are interested in the impact of oxygen tension on stem/progenitor function and how this can be exploited to restore vascular regeneration in disease states and facilitate “re-engineering” of tissue constructs to generate tolerant replacement parts.  As clinical surgeons, we also have abundant access to multiple human tissue types which are frequently used to support our animal findings.  The surgeon-scientist paradigm is unique in that we are in a position to rapidly translate ideas and innovation from the laboratory to clinical trials to really make an impact in the care of patients.

Selected Publications: 

 

  • Chang, E.I., et al. Tissue engineering using autologous microcirculatory beds as vascularized bioscaffolds. FASEB J 23, 906-915 (2009). PMID: 19001054
  • Ceradini, D.J.,et al. Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice. J Biol Chem 283, 10930-10938 (2008). PMID: 18227068
  • Chang, E.I., et al. Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation 116, 2818-2829 (2007). PMID: 18040029
  • Capla, J.M., et al. Diabetes impairs endothelial progenitor cell-mediated blood vessel formation in response to hypoxia. Plast Reconstr Surg 119, 59-70 (2007). PMID: 17255657
  • Kleinman, M.E., et al. Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma. Arterioscler Thromb Vasc Biol 27, 2664-2670 (2007). PMID: 17872454
  • Capla, J.M., et al. Skin graft vascularization involves precisely regulated regression and replacement of endothelial cells through both angiogenesis and vasculogenesis. Plast Reconstr Surg 117, 836-844 (2006). PMID: 16525274
  • Ceradini, D.J.& Gurtner, G.C. Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue. Trends Cardiovasc Med 15, 57-63 (2005). PMID: 15885571
  • Tepper, O.M., et al. Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow-derived cells. Blood 105, 1068-1077 (2005). PMID: 15388583
  • Callaghan, M.J., Ceradini, D.J. & Gurtner, G.C. Hyperglycemia-induced reactive oxygen species and impaired endothelial progenitor cell function. Antioxid Redox Signal 7, 1476-1482 (2005). PMID: 16356110
  • Cetrulo, C.L., Jr., et al. Stem cells and distraction osteogenesis: endothelial progenitor cells home to the ischemic generate in activation and consolidation. Plast Reconstr Surg 116, 1053-1064; discussion 1065-1057 (2005). PMID: 16163094
  • Ceradini, D.J., et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10, 858-864 (2004). PMID: 15235597