Dafna Bar-Sagi, PhD

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Professor of Biochemistry;
Senior Vice President and Vice Dean for Science, Chief Scientific Officer
PhD, 1984 SUNY Stony Brook

LAB WEBSITE:
Bar-Sagi Lab
RESEARCH THEMES:
Signal Transduction, Oncogene function in pancreatic cancer, Ras function
KEYWORDS:
Ras, signal transduction, cancer, inflammation, pancreatic cancer

Contact Information

522 First Ave
2nd Floor, Room 206
Smilow Research Building
New York, NY 10016
Tel: (201)263-0637
E-mail: dafna.bar-sagi@nyumc.org
Website : http://www.med.nyu.edu/biosketch/barsad01


Role of Ras protein in cell proliferation and oncogenic transformation in pancreatic cancer.

 

Epithelia of many organs and tissues turn over quickly and are maintained by known or postulated populations of stem cells that also likely contribute to multiple types of cancers.  The research focus in the lab is on the target cells of pancreatic cancer initiation and their relationship to stem cells.  Specifically, studies in the lab evaluate the molecular and cellular mechanisms, including inflammation and Ras signaling, that instigate pancreatic injury and regeneration.  The relevance of the developmental programs that are activated during this process to pancreatic cancer initiation and progression are being investigated using ex-vivo cell culture systems and in vivo mouse models.

Selected Publications: 
  • Grabocka, E., Y. Pylayeva-Gupta, M.J. Jones, V. Lubkov, E. Yemanaberhan, L. Taylor, H.H. Jeng, and D. Bar-Sagi. (2014). Wild type H- and N-Ras promote mutant K-Ras driven tumorigenesis by modulating the DNA damage response. Cancer Cell. 25: 243-256. PMID: 24525237
  • Commisso, C., Davidson, S.M., Soydaner-Azeloglu, R.G., Parker, Seth J, Kamphorst, J.J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J.A., Thompson, C.B., Rabinowitz, J.D., Metallo, C.M., Vander Heiden, M.G., and D. Bar-Sagi. (2013). Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature 497(7451):633-637. PMID: 23665962
  • Mallen-St Clair, J., Soydaner-Azeloglu, R., Lee, K.E., Taylor, L., Livanos, A., Pylayeva-Gupta, Y., Miller, G., Margueron, R., Reinberg, D., and D. Bar-Sagi. (2012). EZH2 couples pancreatic regeneration to neoplastic progression. Genes & Dev. 26(5):439-444. PMID: 22391448
  • Ochi, A., Nguyen, A.H., Bedrosian, A.S., Mushlin, H.M., Zarbakhsh, S., Barilla, R., Zambirinis, C.P., Fallon, N.C., Rehman, A., Pylayeva-Gupta, Y., Badar, S., Hajdu, C.H., Frey, A.B., Bar-Sagi, D., and G. Miller. (2012). MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med. 209(9):1671-1687. PMID: 22908323
  • Pylayeva-Gupta, Y., K.E. Lee, C.H. Hajdu, G. Miller and D. Bar-Sagi. (2012). Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell 21(6):836-847. PMID: 22698407
  • Patgiri, A., K.K. Yadav, P.S. Arora and D. Bar-Sagi. (2011). An orthosteric inhibitor of the Ras-Sos interaction. Nat. Chem. Biol. 7:585-587. PMID: 21765406
  • Lee, K.E. and D. Bar-Sagi. (2010). Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell 18:448-458. PMID: 21075310