Dafna Bar-sagi, PhD

Dafna-Bar-SagiProfessor of Biochemistry;
Vice Dean for Science and Chief Scientific Officer
PhD, 1984 SUNY Stony Brook

522 First Ave
2nd Floor, Room 206
Smilow Research Building
New York, NY 10016
Tel: (201)263-0637
E-mail: dafna.bar-sagi@nyumc.org
Website : http://www.med.nyu.edu/biosketch/barsad01

Research Theme(s): Oncogene function in pancreatic cancer, signal transduction, Ras function
Keywords: Ras, signal transduction, cancer, inflammation, pancreatic cancer

Research Summary:

Epithelia of many organs and tissues turn over quickly and are maintained by known or postulated populations of stem cells that also likely contribute to multiple types of cancers.  The research focus in the lab is on the target cells of pancreatic cancer initiation and their relationship to stem cells.  Specifically, studies in the lab evaluate the molecular and cellular mechanisms, including inflammation and Ras signaling, that instigate pancreatic injury and regeneration.  The relevance of the developmental programs that are activated during this process to pancreatic cancer initiation and progression are being investigated using ex-vivo cell culture systems and in vivo mouse models.

Selected Publications (2007-2011):